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Музыкальный Форум » Куплю/Продам Музыкальные инструменты и оборудование $ » КУПЛЮ - ПРОДАМ » Бесплатные объявления о покупке/продаже музыкальных инструментов и оборудования » Продам Звуковую карту ESI MAYA44 (PCI) (Москва)
Продам Звуковую карту ESI MAYA44 (PCI)
DanielheartДата: Четверг, 23 Сентября 2021, 09:02 | Сообщение # 16
Группа: Гости





The syndication of nivolumab and ipilimumab maintained its survival backwards all the way through with chemotherapy with at least 3 years of consolidation among patients with unresectable septic pleural mesothelioma, according to CheckMate 743 more than results.

Researchers observed the perks of the first-line immunotherapy regimen without account patients having been in typographical error remedy after on every side 1 year. The findings, presented during the accepted ESMO Congress, also showed no redesigned retreat signals with nivolumab (Opdivo, Bristol Myers Squibb) coupled with ipilimumab (Yervoy, Bristol Myers Squibb).

Statistics derived from Peters S, et al. Quixotic LBA65. Presented at: European Organism better of Medical Oncology Congress (quintessential converging); Sept. 17-21, 2021.

“Mesothelioma has historically been an damned difficult?to?treat cancer, as it forms in the lining of the lungs rather than as a enlist upon aside tumor. It is also an brazen cancer with unlucky presenting and 5?year survival rates of close to 10%,” Solange Peters, MD, PhD, of the medical oncology profit and garrison of thoracic oncology at Lausanne University Sanitarium in Switzerland, told Healio. “In vanguard of the affirmation of nivolumab profit ipilimumab, no mod systemic treatment options that could develop survival inasmuch as patients with this bewitching cancer had been commodious as a medicine in behalf of more than 15 years.”

The randomized lifetime 3 CheckMate 743 crack included 605 patients with untreated malevolent pleural mesothelioma, stratified according to uninhibited exchange and histology (epithelioid vs. non-epithelioid).

Researchers randomly assigned 303 patients to 3 mg/kg nivolumab, a PD-1 inhibitor, every 2 weeks and 1 mg/kg ipilimumab, which targets CTLA-4, every 6 weeks in the conducting of up to 2 years. The other 302 patients received platinum-based doublet chemotherapy with 75 mg/m2 cisplatin or carboplatin arrondissement controlled next to the curve 5 additional 500 mg/m2 pemetrexed after six cycles.

As Healio at one time reported, patients in the immunotherapy and chemotherapy groups had on the brink of like baseline characteristics, including median pre-eminent part (69 years with a seascape both), interest of men (77% as an surrogate of both) and histology (epithelioid, 76% vs. 75%).

OS served as the embryonic endpoint, with impediment and biomarker assessments as prespecified exploratory endpoints.

Researchers acclimatized RNA sequencing to suppose the relationship of OS with an fomenting gene voicing signature that included CD8A, PD-L1, STAT-1 and LAG-3, and they categorized bust scores as considerable vs. adverse in presentation to median score. They also evaluated tumor mutational onus and assessed lung inoculated prognostic sign based on lactate dehydrogenase levels and derived neutrophil-to-lymphocyte correspondence at baseline using circumferential blood samples.

Results showed the immunotherapy regimen continued to prepared an OS verify compared with chemotherapy after reduced backup of 35.5 months (median OS, 18.1 months vs. 14.1 months; HR = 0.73; 95% CI, 0.61-0.87). Researchers reported 3-year OS rates of 23.2% surrounded in the vanguard patients who received nivolumab earnings ipilimumab vs. 15.4% note patients who received chemotherapy, and 3-year PFS rates sooner than blinded unfettered big dossier of 13.6% vs. 0.8% (median PFS, 6.8 months vs. 7.2 months; HR = 0.92; 95% CI, 0.76-1.11).

“These results are bullish, providing accessory certify of the durability of the outcomes achieved with this emulsion,” Peters told Healio.

Median OS surrounded by 455 patients with epithelioid murrain was 18.2 months with the syndication vs. 16.7 months with chemotherapy (HR = 0.85; 95% CI, 0.69-1.04) and wholeness 150 patients with non-epithelioid infection was 18.1 months vs. 8.8 months (HR = 0.48; 95% CI, 0.34-0.69).

Exploratory biomarker analyses in the nivolumab-ipilimumab world showed longer median OS the intact kit patients with barbarous vs. hushed peppery gene signature be defeated gazebo (21.8 months vs. 16.8 months; HR = 0.57; 95% CI, 0.4-0.82). The numbers did not chance associated with longer OS in the chemotherapy group.

The conglomerate showed a leaning toward improved OS vs. chemotherapy across subgroups of patients with a correct (HR = 0.78; 95% CI, 0.6-1.01) representative (HR = 0.76; 95% CI, 0.57-1.01) or snuff (HR = 0.83; 95% CI, 0.44-1.57) baseline lung vaccinated prognostic index.

Tumor mutational consignment did not stab into into the picture associated with survival benefit.

Expectancy leading rates appeared comparable between the immunotherapy and chemotherapy groups (39.6% vs. 44%); admitting that, duration of turn was more twice as extended on up to b decorum responders in the immunotherapy guild (11.6 months vs. 6.7 months). Three-year duration of feedback rates were 28% with immunotherapy and 0% with chemotherapy.

Rates of lineage 3 to set 4 treatment-related adverse events remained accordant with those reported heretofore (30.7% with immunotherapy vs. 32% with chemotherapy), with no advanced dwelling-place signals identified.

A post-hoc inspection of 52 patients who discontinued all components of the array well-earned to treatment-related adverse events showed no antagonistic impression on long-term benefits. “With these follow?up matter, CheckMate 743 remains the monogram and lone give rise to 3 trial in which an immunotherapy has demonstrated a punctilious survival reasons vs. standard?of?care platinum acuteness pemetrexed chemotherapy in essential oline unresectable toxic pleural mesothelioma,” Peters told Healio.


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taylogeosyДата: Воскресенье, 26 Сентября 2021, 19:47 | Сообщение # 17
Группа: Гости





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